| First Author | Sansom OJ | Year | 2005 |
| Journal | Oncogene | Volume | 24 |
| Issue | 55 | Pages | 8205-10 |
| PubMed ID | 16116480 | Mgi Jnum | J:104413 |
| Mgi Id | MGI:3611954 | Doi | 10.1038/sj.onc.1208956 |
| Citation | Sansom OJ, et al. (2005) Apc deficiency predisposes to renal carcinoma in the mouse. Oncogene 24(55):8205-10 |
| abstractText | Deregulation of Wnt signalling has recently been implicated in human renal cancer. Here, we directly test this association by using a Cre-LoxP strategy to inactivate the Adenomatous Polyposis Coli (Apc) gene in the murine renal epithelium. Mice homozygous for a conditional Apc allele were intercrossed with mice transgenic for Cre recombinase under control of the Cyp1A promoter, which delivers constitutive recombination within a proportion of cells in the renal epithelium. Inactivation of Apc leads to the accumulation of nuclear beta-catenin and the rapid development of multiple dysplastic foci. Renal carcinoma was observed with an earliest onset of 4 months. This predisposition was accelerated by p53 deficiency, reducing the earliest onset to 2 months. Compared to other murine models of kidney neoplasia, this represents particularly rapid onset of disease, and so implicates an important role for Apc in suppressing renal carcinoma. |
