| First Author | Meyers EN | Year | 1999 |
| Journal | Science | Volume | 285 |
| Issue | 5426 | Pages | 403-6 |
| PubMed ID | 10411502 | Mgi Jnum | J:56374 |
| Mgi Id | MGI:1340887 | Doi | 10.1126/science.285.5426.403 |
| Citation | Meyers EN, et al. (1999) Differences in left-right axis pathways in mouse and chick: functions of FGF8 and SHH. Science 285(5426):403-6 |
| abstractText | A molecular pathway leading to left-right asymmetry in the chick embryo has been described, in which FGF8 is a right determinant and Sonic Hedgehog a left determinant. Here evidence is presented that the Fgf8 and Sonic Hedgehog genes are required for left-right axis determination in the mouse embryo, but that they have different functions from those previously reported in the chick. In the mouse FGF8 is a left determinant and Sonic Hedgehog is required to prevent left determinants from being expressed on the right. |
