| Primary Identifier | MGI:1857856 | Allele Type | Targeted |
| Attribute String | Null/knockout, Reporter | Gene | Hnf1b |
| Transmission | Germline | Strain of Origin | 129P2/OlaHsd-Hprt1<b-m3> |
| Is Recombinase | false | Is Wild Type | false |
| molecularNote | Exon 1 was replaced by a construct containing lacZ and neo. The deleted coding sequence encodes the entire N-terminal dimerization domain and a portion of another domain showing homology to either the human POU-A subdomain or human B-domain. Western blot analysis showed an absence of encoded protein in homozygous mutant embryos. Beta-galactosidase was expressed under the control of the endogenous promoter. |
