| First Author | Kurahashi T | Year | 2012 |
| Journal | FEBS Lett | Volume | 586 |
| Issue | 24 | Pages | 4289-95 |
| PubMed ID | 23098755 | Mgi Jnum | J:191746 |
| Mgi Id | MGI:5462502 | Doi | 10.1016/j.febslet.2012.09.047 |
| Citation | Kurahashi T, et al. (2012) A malfunction in triglyceride transfer from the intracellular lipid pool to apoB in enterocytes of SOD1-deficient mice. FEBS Lett 586(24):4289-95 |
| abstractText | We compared lipid metabolism in the intestines of Sod1-knockout mice with that found in wild-type mice to elucidate the impact of oxidative stress in vivo. A high-fat diet in wild-type mice induced postprandial hypertriglyceridemia, but this adaptive response was impaired in Sod1-knockout mice. While fewer triglycerides were secreted to the blood in the form of triglyceride-rich lipoprotein, more lipid droplets accumulated in the enterocytes of Sod1-knockout mice fed a high-fat diet. These data collectively suggest that high-fat diet induces oxidative stress, inhibits lipid secretion to the blood, and ultimately leads to dysfunctional lipid metabolism in enterocytes. |
