| First Author | Cotena A | Year | 2004 |
| Journal | J Immunol | Volume | 173 |
| Issue | 10 | Pages | 6427-32 |
| PubMed ID | 15528383 | Mgi Jnum | J:94284 |
| Mgi Id | MGI:3511741 | Doi | 10.4049/jimmunol.173.10.6427 |
| Citation | Cotena A, et al. (2004) The class A macrophage scavenger receptor attenuates CXC chemokine production and the early infiltration of neutrophils in sterile peritonitis. J Immunol 173(10):6427-32 |
| abstractText | The macrophage scavenger receptor (SR-A) is a multifunctional receptor that is associated with several important pathological conditions, including atherosclerosis. In this study, we show, using a sterile peritonitis model, that it can regulate the inflammatory response. SR-A null mice display an increased initial granulocytic infiltration because of overproduction of the CXC chemokines, MIP-2 and keratinocyte-derived cytokine. This differential response is dependent upon particle internalization and can be mimicked by advanced glycation end product-BSA-conjugated latex beads. Thus SR-A is a nonactivating receptor, which is the first example of a pattern recognition receptor that serves to counter the activities of proinflammatory receptors and attenuates the production of specific chemokines to ensure an inflammatory response of the appropriate magnitude. |
