| First Author | Sim HR | Year | 2013 |
| Journal | Nat Commun | Volume | 4 |
| Pages | 1579 | PubMed ID | 23481387 |
| Mgi Jnum | J:279561 | Mgi Id | MGI:6363377 |
| Doi | 10.1038/ncomms2598 | Citation | Sim HR, et al. (2013) Role of dopamine D2 receptors in plasticity of stress-induced addictive behaviours. Nat Commun 4:1579 |
| abstractText | Dopaminergic systems are implicated in stress-related behaviour. Here we investigate behavioural responses to chronic stress in dopamine D2 receptor knockout mice and find that anxiety-like behaviours are increased compared with wild-type mice. Repeated stress exposure suppresses cocaine-induced behavioural sensitization, cocaine-seeking and relapse behaviours in dopamine D2 receptor knockout mice. Cocaine challenge after drug withdrawal in cocaine-experienced wild-type or dopamine D2 receptor knockout mice is associated with inhibition of long-term depression in the nucleus accumbens, and chronic stress during withdrawal prevents inhibition after cocaine challenge in cocaine-experienced dopamine D2 receptor knockout mice, but not in wild-type mice. Lentiviral-induced knockdown of dopamine D2 receptors in the nucleus accumbens of wild-type mice does not affect basal locomotor activity, but confers stress-induced inhibition of the expression of cocaine-induced behavioural sensitization. Stressed mice depleted of dopamine D2 receptors do not manifest long-term depression inhibition. Our results suggest that dopamine D2 receptors have roles in regulating synaptic modification triggered by stress and drug addiction. |
