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Publication : High lethality of F1 (Dh/+) male mice from the cross between DDD female and DH (Dh/+) male.

First Author  Suto J Year  1996
Journal  Exp Anim Volume  45
Issue  1 Pages  99-101
PubMed ID  8689589 Mgi Jnum  J:31338
Mgi Id  MGI:78841 Doi  10.1538/expanim.45.99
Citation  Suto J, et al. (1996) High lethality of F1 (Dh/+) male mice from the cross between DDD female and DH (Dh/+) male. Exp Anim 45(1):99-101
abstractText  The present study demonstrates the incidence of high lethality of F1 (Dh/+) male mice, the offspring of DDD females and inbred DH (Dh/+) males. Among the newborn pups, the numbers of F1 (Dh/+) males are comparable to those of mice having other genotypes (+/+ male, Dh/+ female and +/+ female), but many F1 (Dh/+) males died before weaning. On the other hand, among the F1 mice from the cross between DH (Dh/+) females and DDD males, there are no biased numbers of Dh genotype pups. These results suggest the existence of defects in the interaction between the male derived Dh gene and the genetic traits of the DDD female.
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