| First Author | Higgins M | Year | 1992 |
| Journal | Genet Res | Volume | 60 |
| Issue | 1 | Pages | 53-60 |
| PubMed ID | 1360439 | Mgi Jnum | J:2793 |
| Mgi Id | MGI:51315 | Doi | 10.1017/s0016672300030664 |
| Citation | Higgins M, et al. (1992) Dominant hemimelia and En-1 on mouse chromosome 1 are not allelic. Genet Res 60(1):53-60 |
| abstractText | Previous studies have shown that En-1, a homeobox-containing gene, maps close to or at the Dh locus in the mouse. Since homeobox-containing genes are key genes in the control of development the close proximity of En-1 to the developmentally significant gene Dh raised the possibility that the Dh mutation represented a mutant allele of En-1. A genetic analysis involving En-1, Dh, and other chromosome 1 markers (Emv-17, ln and Pep-3) shows that although Dh and En-1 are closely linked they are separable by recombination (4/563). The likely gene order and recombination frequencies of these loci are: ln (5.2 +/- 0.9) Emv-17 (1.1 +/- 0.4) Dh (0.7 +/- 0.4) En-1 (3.0 +/- 0.7) Pep-3. This shows that Dh is not a mutant allele of En-1. |
