| First Author | Okada T | Year | 2002 |
| Journal | J Exp Med | Volume | 196 |
| Issue | 1 | Pages | 65-75 |
| PubMed ID | 12093871 | Mgi Jnum | J:77506 |
| Mgi Id | MGI:2181902 | Doi | 10.1084/jem.20020201 |
| Citation | Okada T, et al. (2002) Chemokine requirements for B cell entry to lymph nodes and Peyer's patches. J Exp Med 196(1):65-75 |
| abstractText | B cell entry to lymph nodes and Peyer's patches depends on chemokine receptor signaling, but the principal chemokine involved has not been defined. Here we show that the homing of CXCR4-/- B cells is suppressed in CCL19 (ELC)- and CCL21 (SLC)-deficient paucity of lymph node T cells mice, but not in wild-type mice. We also find that CXCR4 can contribute to T cell homing. Using intravital microscopy, we find that B cell adhesion to high endothelial venules (HEVs) is disrupted when CCR7 and CXCR4 are predesensitized. In Peyer's patches, B cell entry is dependent on CXCR5 in addition to CCR7/CXCR4. CXCL12 (SDF1) is displayed broadly on HEVs, whereas CXCL13 (BLC) is found selectively on Peyer's patch follicular HEVs. These findings establish the principal chemokine and chemokine receptor requirements for B cell entry to lymph nodes and Peyer's patches. |
