| First Author | Hasty P | Year | 1995 |
| Journal | Somat Cell Mol Genet | Volume | 21 |
| Issue | 3 | Pages | 177-87 |
| PubMed ID | 7482032 | Mgi Jnum | J:29656 |
| Mgi Id | MGI:77181 | Doi | 10.1007/BF02254769 |
| Citation | Hasty P, et al. (1995) Severe phenotype in mice with termination mutation in exon 2 of cystic fibrosis gene. Somat Cell Mol Genet 21(3):177-87 |
| abstractText | Mice with a termination codon mutation in exon 2 of the cystic fibrosis (CF) gene were generated using homologous recombination in embryonic stem cells. Animals homozygous for the mutant allele display a severe intestinal phenotype similar to that previously reported for CF mutant mice. The null nature of this allele was demonstrated by the absence of detectable wild-type mRNA, by the absence of detectable CFTR in the serous gland collecting ducts of salivary tissues, and by the lack of cAMP-mediated short-circuit current responses in colonic epithelium of mutant animals. |
