| First Author | Witt CM | Year | 2003 |
| Journal | J Immunol | Volume | 171 |
| Issue | 6 | Pages | 2783-8 |
| PubMed ID | 12960298 | Mgi Jnum | J:85379 |
| Mgi Id | MGI:2674204 | Doi | 10.4049/jimmunol.171.6.2783 |
| Citation | Witt CM, et al. (2003) Notch2 haploinsufficiency results in diminished B1 B cells and a severe reduction in marginal zone B cells. J Immunol 171(6):2783-8 |
| abstractText | Recent studies have implicated a role for Notch in the generation of marginal zone (MZ) B cells. To further investigate the role of Notch in the B cell lineage, we have analyzed the effects of reduced Notch2 signaling in mice expressing one functional allele of Notch2 (Notch2(+/-)). Notch2(+/-) mice have reduced B1 B cells of the peritoneal cavity and show a severe reduction in MZ B cells of the spleen. The reduction in MZ B cells was not due to the disruption of splenic architecture, disregulated terminal differentiation, nor to increased apoptosis within the MZ B cell compartment. Rather, our data suggest that Notch2 haploinsufficiency leads to impaired development of MZ B cells, possibly by impacting the formation of immediate MZ B precursors. These results provide evidence that Notch2 plays a determining role in the development and/or the maintenance of B1 B and MZ B cells. |
