| Primary Identifier | MGI:1857794 | Allele Type | Spontaneous |
| Gene | Nox3 | Inheritance Mode | Recessive |
| Strain of Origin | B10.Q-H2<q>/SgJ | Is Recombinase | false |
| Is Wild Type | false |
| description | The head-leaning and circling are more dramatic than the original het mutation. However, ABR (auditory-evoked brainstem response) testing of three 5-week old homozygotes and heterozygotes showed normal hearing indistinquishable from wild-type controls and the original het/het mutants. Viability and fertility of both sexes of mice are normal; although trampling of pups is common(J:56803). |
| molecularNote | The mutation in the het-2J mouse was identified as a G-to-A substitution at coding nucleotide position 1222 (c.1222G>A), replacing a glycine residue with an arginine at position 408 (p.G408R). The glycine residue is highly conserved and is part of an NADPH binding site. |
