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Publication : CDON contributes to Hedgehog-dependent patterning and growth of the developing limb.

First Author  Echevarría-Andino ML Year  2022
Journal  Dev Biol Volume  493
Pages  1-11 PubMed ID  36265686
Mgi Jnum  J:330830 Mgi Id  MGI:7380221
Doi  10.1016/j.ydbio.2022.09.011 Citation  Echevarria-Andino ML, et al. (2022) CDON contributes to Hedgehog-dependent patterning and growth of the developing limb. Dev Biol 493:1-11
abstractText  Hedgehog (HH) signaling is a major driver of tissue patterning during embryonic development through the regulation of a multitude of cell behaviors including cell fate specification, proliferation, migration, and survival. HH ligands signal through the canonical receptor PTCH1 and three co-receptors, GAS1, CDON and BOC. While previous studies demonstrated an overlapping and collective requirement for these co-receptors in early HH-dependent processes, the early embryonic lethality of Gas1;Cdon;Boc mutants precluded an assessment of their collective contribution to later HH-dependent signaling events. Specifically, a collective role for these co-receptors during limb development has yet to be explored. Here, we investigate the combined contribution of these co-receptors to digit specification, limb patterning and long bone growth through limb-specific conditional deletion of Cdon in a Gas1;Boc null background. Combined deletion of Gas1, Cdon and Boc in the limb results in digit loss as well as defects in limb outgrowth and long bone patterning. Taken together, these data demonstrate that GAS1, CDON and BOC are collectively required for HH-dependent patterning and growth of the developing limb.
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