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Publication : Shape analysis of the basioccipital bone in Pax7-deficient mice.

First Author  Cates J Year  2017
Journal  Sci Rep Volume  7
Issue  1 Pages  17955
PubMed ID  29263370 Mgi Jnum  J:287270
Mgi Id  MGI:6415813 Doi  10.1038/s41598-017-18199-9
Citation  Cates J, et al. (2017) Shape analysis of the basioccipital bone in Pax7-deficient mice. Sci Rep 7(1):17955
abstractText  We compared the cranial base of newborn Pax7-deficient and wildtype mice using a computational shape modeling technology called particle-based modeling (PBM). We found systematic differences in the morphology of the basiooccipital bone, including a broadening of the basioccipital bone and an antero-inferior inflection of its posterior edge in the Pax7-deficient mice. We show that the Pax7 cell lineage contributes to the basioccipital bone and that the location of the Pax7 lineage correlates with the morphology most effected by Pax7 deficiency. Our results suggest that the Pax7-deficient mouse may be a suitable model for investigating the genetic control of the location and orientation of the foramen magnum, and changes in the breadth of the basioccipital.
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