| First Author | Messina G | Year | 2010 |
| Journal | Cell | Volume | 140 |
| Issue | 4 | Pages | 554-66 |
| PubMed ID | 20178747 | Mgi Jnum | J:160383 |
| Mgi Id | MGI:4454367 | Doi | 10.1016/j.cell.2010.01.027 |
| Citation | Messina G, et al. (2010) Nfix regulates fetal-specific transcription in developing skeletal muscle. Cell 140(4):554-66 |
| abstractText | Skeletal myogenesis, like hematopoiesis, occurs in successive developmental stages that involve different cell populations and expression of different genes. We show here that the transcription factor nuclear factor one X (Nfix), whose expression is activated by Pax7 in fetal muscle, in turn activates the transcription of fetal specific genes such as MCK and beta-enolase while repressing embryonic genes such as slow myosin. In the case of the MCK promoter, Nfix forms a complex with PKC theta that binds, phosphorylates, and activates MEF2A. Premature expression of Nfix activates fetal and suppresses embryonic genes in embryonic muscle, whereas muscle-specific ablation of Nfix prevents fetal and maintains embryonic gene expression in the fetus. Therefore, Nfix acts as a transcriptional switch from embryonic to fetal myogenesis. |
