| First Author | Nobs SP | Year | 2015 |
| Journal | Immunity | Volume | 43 |
| Issue | 4 | Pages | 674-89 |
| PubMed ID | 26453378 | Mgi Jnum | J:233862 |
| Mgi Id | MGI:5788230 | Doi | 10.1016/j.immuni.2015.09.006 |
| Citation | Nobs SP, et al. (2015) PI3-Kinase-gamma Has a Distinct and Essential Role in Lung-Specific Dendritic Cell Development. Immunity 43(4):674-89 |
| abstractText | Development of dendritic cells (DCs) commences in the bone marrow, from where pre-DCs migrate to peripheral organs to differentiate into mature DCs in situ. However, the factors that regulate organ-specific differentiation to give rise to tissue-specific DC subsets remain unclear. Here we show that the Ras-PI3Kgamma-Akt-mTOR signaling axis acted downstream of FLT3L signaling and was required for development of lung CD103(+) DCs and, to a smaller extent, for lung CD11b(+) DCs, but not related DC populations in other non-lymphoid organs. Furthermore, we show that in lymphoid organs such as the spleen, DCs depended on a similar signaling network to respond to FLT3 ligand with overlapping and partially redundant roles for kinases PI3Kgamma and PI3Kdelta. Thus we identified PI3Kgamma as an essential organ-specific regulator of lung DC development and discovered a signaling network regulating tissue-specific DC development mediated by FLT3. |
