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Allele : Met<tm1Cpo> met proto-oncogene; targeted mutation 1, Carola Ponzetto

Primary Identifier  MGI:1858019 Allele Type  Targeted
Attribute String  Humanized sequence, Inserted expressed sequence Gene  Met
Transmission  Germline Strain of Origin  (129X1/SvJ x 129S1/Sv)F1-Kitl<+>
Is Recombinase  false Is Wild Type  false
molecularNote  A mutant human cDNA coding for the transmembrane and cytoplasmic domain of the receptor was inserted in-frame into mouse genomic sequences. The cDNA was followed by a neomycin resistance cassette. A fusion protein consisting of the murine extracellular domain fused to the human transmembrane and cytoplasmic domain carrying the mutations Y1349F and Y1356Fis produced from this allele.
  • mutations:
  • Insertion
  • synonyms:
  • Met<->,
  • Met<->,
  • Met<D>,
  • met<d>,
  • met<d>,
  • Met<D>
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1 Feature

Trail: Allele

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

0 Carried By

0 Driven By

19 Publication categories

Trail: Allele