| Primary Identifier | MGI:1858026 | Allele Type | Spontaneous |
| Gene | Crygd | Inheritance Mode | Semidominant |
| Strain of Origin | BALB/cJ x SJL/J | Is Recombinase | false |
| Is Wild Type | false |
| description | Both homozygous and heterozygous mutant mice develop cataracts by one month of age. The catarats demonstrate prominent reactive fibrous proliferation surrounding extruded lens cortical fragments, accompanied by focal, mild lymphocytic infiltration. Homozygous mice have eyes that are smaller than wildtype, whereas the heterozygote mouse has an eye size that is intermediate (J:60856). |
| molecularNote | A G-to-A transition (C-to-T on forward strand) at coding nucleotide position 470 in exon 3 creates a premature termination signal by changing tryptophan codon 157 to a stop codon (p.W157*) and results in a truncated protein after amino acid 156. |
