| Primary Identifier | MGI:1858045 | Allele Type | Transgenic |
| Gene | Hr | Inheritance Mode | Recessive |
| Strain of Origin | (C57BL/6 x C3H/He)F2 | Is Recombinase | false |
| Is Wild Type | false |
| description | PCR analysis of flanking markers suggest that the transgene insertion site occurred in the C57BL/6J parent. This allele of Hr was induced by transgenic insertion of a construct with an amylase/elastase enhancer/promotor directing expression of the bacterial chloramphenicolacetyl transferase reporter gene. The clinical and histological phenotype of this mutant closely resembles the phenotype of rhino allele mutants (J:15642). |
| molecularNote | This allele was initially defined by a noncomplementation test with hr and subsequently found to be the result of the integration of a 2 kb construct, M2CAT ,containing an amylase/elastase enhancer/promoter, between intron 5 and exon 8 of the hairless gene, and deletion of the 3-prime portion of the gene |
