| First Author | Sachidhanandam S | Year | 2009 |
| Journal | J Neurosci | Volume | 29 |
| Issue | 15 | Pages | 5000-8 |
| PubMed ID | 19369569 | Mgi Jnum | J:147953 |
| Mgi Id | MGI:3843089 | Doi | 10.1523/JNEUROSCI.5807-08.2009 |
| Citation | Sachidhanandam S, et al. (2009) Kainate receptors act as conditional amplifiers of spike transmission at hippocampal mossy fiber synapses. J Neurosci 29(15):5000-8 |
| abstractText | Hippocampal mossy fiber (Mf) synapses are viewed as conditional detonators, assisting CA3 cells in complex network functions. By analyzing mice deficient for GluK2 (GluR6), GluK3 (GluR7) and GluK5 (KA2) genes we show that kainate receptors (KARs) play a crucial role in the control of synaptic integration and spike transmission efficacy at Mf synapses. We dissected out the role of the different KAR functions at Mf synapses and we show that presynaptic and postsynaptic KARs concur to amplify unitary Mf synaptic inputs to trigger spike discharge within a wide range of frequencies (from 1 to 50 Hz). Moreover, KARs strongly favor spike transmission in response to patterns of presynaptic activity mimicking in vivo dentate granule cell activity. By amplifying spike transmission, KARs also facilitate the induction of associative long-term potentiation in CA3. Hence the actions of KARs as amplifiers of spike transmission contribute largely to the 'conditional detonator' function of Mf synapses and are likely important for spatial information processing. |
