| First Author | Levenes C | Year | 1997 |
| Journal | Neuroreport | Volume | 8 |
| Issue | 2 | Pages | 571-4 |
| PubMed ID | 9080450 | Mgi Jnum | J:41533 |
| Mgi Id | MGI:894011 | Doi | 10.1097/00001756-199701200-00038 |
| Citation | Levenes C, et al. (1997) Incomplete regression of multiple climbing fibre innervation of cerebellar Purkinje cells in mGLuR1 mutant mice. Neuroreport 8(2):571-4 |
| abstractText | Recent reports have suggested the existence of a causal relationship between impaired regression of multiple climbing fibre innervation and impaired motor coordination in protein kinase C gamma subunit (PKC gamma) mutant mice. In the present patch-clamp study, performed in thin cerebellar slices prepared from adult mutant mice deficient in metabotropic glutamate receptors of the mGluR1 subtype, only 15% of Purkinje cells remained multiply innervated by climbing fibres, but motor coordination was largely impaired in these animals. The present results do not preclude the existence of a causal relationship between impairement of regression of multiple innervation during development and improper motor coordination in the adult. |
