| First Author | Ichise T | Year | 2000 |
| Journal | Science | Volume | 288 |
| Issue | 5472 | Pages | 1832-5 |
| PubMed ID | 10846166 | Mgi Jnum | J:62729 |
| Mgi Id | MGI:1859499 | Doi | 10.1126/science.288.5472.1832 |
| Citation | Ichise T, et al. (2000) mGluR1 in cerebellar Purkinje cells essential for long-term depression, synapse elimination, and motor coordination. Science 288(5472):1832-5 |
| abstractText | Targeted deletion of metabotropic glutamate receptor-subtype 1 (mGluR1) gene can cause defects in development and function in the cerebellum. We introduced the mGluR1alpha transgene into mGluR1-null mutant [mGluR1 (-/-)] mice with a Purkinje cell (PC)-specific promoter. mGluR1-rescue mice showed normal cerebellar long-term depression and regression of multiple climbing fiber innervation, events significantly impaired in mGluR1 (-/-) mice. The impaired motor coordination was rescued by this transgene, in a dose-dependent manner. We propose that mGluR1 in PCs is a key molecule for normal synapse formation, synaptic plasticity, and motor control in the cerebellum. |
