| First Author | Jaegle M | Year | 1996 |
| Journal | Science | Volume | 273 |
| Issue | 5274 | Pages | 507-10 |
| PubMed ID | 8662541 | Mgi Jnum | J:34465 |
| Mgi Id | MGI:81922 | Doi | 10.1126/science.273.5274.507 |
| Citation | Jaegle M, et al. (1996) The POU factor Oct-6 and Schwann cell differentiation. Science 273(5274):507-10 |
| abstractText | The POU transcription factor Oct-6, also known as SCIP or Tst-1, has been implicated as a major transcriptional regulator in Schwann cell differentiation. Microscopic and immunochemical analysis of sciatic nerves of Oct-6(-/-) mice at different stages of postnatal development reveals a delay in Schwann cell differentiation, with a transient arrest at the promyelination stage. Thus, Oct-6 appears to be required for the transition of promyelin cells to myelinating cells. Once these cells progress past this point, Oct-6 is no longer required, and myelination occurs normally. |
