| First Author | Li MY | Year | 2017 |
| Journal | Neuron | Volume | 94 |
| Issue | 6 | Pages | 1155-1172.e8 |
| PubMed ID | 28641114 | Mgi Jnum | J:253234 |
| Mgi Id | MGI:6109832 | Doi | 10.1016/j.neuron.2017.05.022 |
| Citation | Li MY, et al. (2017) A Critical Role of Presynaptic Cadherin/Catenin/p140Cap Complexes in Stabilizing Spines and Functional Synapses in the Neocortex. Neuron 94(6):1155-1172.e8 |
| abstractText | The formation of functional synapses requires coordinated assembly of presynaptic transmitter release machinery and postsynaptic trafficking of functional receptors and scaffolds. Here, we demonstrate a critical role of presynaptic cadherin/catenin cell adhesion complexes in stabilizing functional synapses and spines in the developing neocortex. Importantly, presynaptic expression of stabilized beta-catenin in either layer (L) 4 excitatory neurons or L2/3 pyramidal neurons significantly upregulated excitatory synaptic transmission and dendritic spine density in L2/3 pyramidal neurons, while its sparse postsynaptic expression in L2/3 neurons had no such effects. In addition, presynaptic beta-catenin expression enhanced release probability of glutamatergic synapses. Newly identified beta-catenin-interacting protein p140Cap is required in the presynaptic locus for mediating these effects. Together, our results demonstrate that cadherin/catenin complexes stabilize functional synapses and spines through anterograde signaling in the neocortex and provide important molecular evidence for a driving role of presynaptic components in spinogenesis in the neocortex. |
