| First Author | Chassot AA | Year | 2017 |
| Journal | Dev Biol | Volume | 426 |
| Issue | 1 | Pages | 17-27 |
| PubMed ID | 28456466 | Mgi Jnum | J:243209 |
| Mgi Id | MGI:5907923 | Doi | 10.1016/j.ydbio.2017.04.010 |
| Citation | Chassot AA, et al. (2017) Constitutive WNT/CTNNB1 activation triggers spermatogonial stem cell proliferation and germ cell depletion. Dev Biol 426(1):17-27 |
| abstractText | The differentiation of germ cells into oogonia or spermatogonia is the first step that eventually gives rise to fully mature gametes. In the female fetal gonad, the RSPO1/WNT/CTNNB1 signalling pathway is involved in primordial germ cell proliferation and differentiation into female germ cells, which are able to enter meiosis. In the postnatal testis, the WNT/CTNNB1 pathway also mediates proliferation of spermatogonial stem cells and progenitor cells. Here we show that forced activation of the WNT/CTNNB1 pathway in fetal gonocytes using transgenic mice leads to deregulated spermatogonial proliferation, and exhaustion of the spermatocytes by apoptosis, resulting in a hypoplastic testis. These findings demonstrate that a finely tuned timing in WNT/CTNNB1 signalling activity is required for spermatogenesis. |
