| First Author | Heiser PW | Year | 2006 |
| Journal | Development | Volume | 133 |
| Issue | 10 | Pages | 2023-32 |
| PubMed ID | 16611688 | Mgi Jnum | J:108521 |
| Mgi Id | MGI:3624194 | Doi | 10.1242/dev.02366 |
| Citation | Heiser PW, et al. (2006) Stabilization of {beta}-catenin impacts pancreas growth. Development 133(10):2023-32 |
| abstractText | A recent study has shown that deletion of beta-catenin within the pancreatic epithelium results in a loss of pancreas mass. Here, we show that ectopic stabilization of beta-catenin within mouse pancreatic epithelium can have divergent effects on both organ formation and growth. Robust stabilization of beta-catenin during early organogenesis drives changes in hedgehog and Fgf10 signaling and induces a loss of Pdx1 expression in early pancreatic progenitor cells. Together, these perturbations in early pancreatic specification culminate in a severe reduction of pancreas mass and postnatal lethality. By contrast, inducing the stabilized form of beta-catenin at a later time point in pancreas development causes enhanced proliferation that results in a dramatic increase in pancreas organ size. Taken together, these data suggest a previously unappreciated temporal/spatial role for beta-catenin signaling in the regulation of pancreas organ growth. |
