| First Author | Deschene ER | Year | 2014 |
| Journal | Science | Volume | 343 |
| Issue | 6177 | Pages | 1353-6 |
| PubMed ID | 24653033 | Mgi Jnum | J:209582 |
| Mgi Id | MGI:5568151 | Doi | 10.1126/science.1248373 |
| Citation | Deschene ER, et al. (2014) beta-Catenin activation regulates tissue growth non-cell autonomously in the hair stem cell niche. Science 343(6177):1353-6 |
| abstractText | Wnt/beta-catenin signaling is critical for tissue regeneration. However, it is unclear how beta-catenin controls stem cell behaviors to coordinate organized growth. Using live imaging, we show that activation of beta-catenin specifically within mouse hair follicle stem cells generates new hair growth through oriented cell divisions and cellular displacement. beta-Catenin activation is sufficient to induce hair growth independently of mesenchymal dermal papilla niche signals normally required for hair regeneration. Wild-type cells are co-opted into new hair growths by beta-catenin mutant cells, which non-cell autonomously activate Wnt signaling within the neighboring wild-type cells via Wnt ligands. This study demonstrates a mechanism by which Wnt/beta-catenin signaling controls stem cell-dependent tissue growth non-cell autonomously and advances our understanding of the mechanisms that drive coordinated regeneration. |
