| First Author | Soshnikova N | Year | 2003 |
| Journal | Genes Dev | Volume | 17 |
| Issue | 16 | Pages | 1963-8 |
| PubMed ID | 12923052 | Mgi Jnum | J:84878 |
| Mgi Id | MGI:2670493 | Doi | 10.1101/gad.263003 |
| Citation | Soshnikova N, et al. (2003) Genetic interaction between Wnt/beta-catenin and BMP receptor signaling during formation of the AER and the dorsal-ventral axis in the limb. Genes Dev 17(16):1963-8 |
| abstractText | By conditional gene ablation in mice, we found that beta-catenin, an essential downstream effector of canonical Wnt signaling, is a key regulator of formation of the apical ectodermal ridge (AER) and of the dorsal-ventral axis of the limbs. By generation of compound mutants, we also show that beta-catenin acts downstream of the BMP receptor IA in AER induction, but upstream or parallel in dorsal-ventral patterning. Thus, AER formation and dorsal-ventral patterning of limbs are tightly controlled by an intricate interplay between Wnt/beta-catenin and BMP receptor signaling. |
