| First Author | Bekiaris V | Year | 2009 |
| Journal | Eur J Immunol | Volume | 39 |
| Issue | 8 | Pages | 2120-5 |
| PubMed ID | 19609980 | Mgi Jnum | J:152086 |
| Mgi Id | MGI:4356209 | Doi | 10.1002/eji.200939424 |
| Citation | Bekiaris V, et al. (2009) Synergistic OX40 and CD30 signals sustain CD8+ T cells during antigenic challenge. Eur J Immunol 39(8):2120-5 |
| abstractText | Prior to acquiring a memory phenotype, antigen-activated CD8(+) T cells need to expand and then undergo a contraction phase. Utilizing two different antigenic stimuli, we provide evidence that the tumor necrosis factor receptors OX40 and CD30 integrate synergistic signals during the expansion phase to help maintain CD8(+) effectors. Thus, double deficiency in OX40 and CD30 leads to CD8(+) cell loss during expansion after immunization either with OVA or with murine CMV. Following their contraction, OX40- and CD30-deficient CD8(+) T cells persist normally in CMV-infected mice. In contrast, persistence after OVA challenge is dependent on OX40 and CD30. Collectively, our data define the important role of both OX40 and CD30 during CD8(+) T-cell activation, and show that long-term CD8 persistence after contraction is regulated not only by stimulatory receptors but also by the nature of the antigen or how the antigen is presented. |
