| First Author | Stemmelin J | Year | 2010 |
| Journal | Behav Brain Res | Volume | 206 |
| Issue | 2 | Pages | 310-2 |
| PubMed ID | 19744528 | Mgi Jnum | J:153973 |
| Mgi Id | MGI:4366666 | Doi | 10.1016/j.bbr.2009.09.003 |
| Citation | Stemmelin J, et al. (2010) Implication of beta3-adrenoceptors in the antidepressant-like effects of amibegron using Adrb3 knockout mice in the chronic mild stress. Behav Brain Res 206(2):310-2 |
| abstractText | The involvement of the beta3-adrenoceptor in the antidepressant-like effects of the beta3-adrenoceptor-agonist amibegron is addressed in the chronic mild stress, using adrenergic beta3-receptor knockout (Adrb3tm1Lowl) mice. Amibegron (3 mg/kg/day, i.p., 33 days), attenuated the physical alteration due to the application of repeated stress in wild-type littermates, but not in knockout mice. This result suggests that the beta3-adrenoceptor plays a predominant role in mediating antidepressant-like actions of amibegron. |
