| First Author | Kistowska M | Year | 2014 |
| Journal | J Invest Dermatol | Volume | 134 |
| Issue | 3 | Pages | 677-685 |
| PubMed ID | 24157462 | Mgi Jnum | J:206191 |
| Mgi Id | MGI:5548054 | Doi | 10.1038/jid.2013.438 |
| Citation | Kistowska M, et al. (2014) IL-1beta Drives Inflammatory Responses to Propionibacterium acnes In Vitro and In Vivo. J Invest Dermatol 134(3):677-85 |
| abstractText | Acne vulgaris is potentially a severe skin disease associated with colonization of the pilo-sebaceous unit by the commensal bacterium Propionibacterium acnes and inflammation. P. acnes is considered to contribute to inflammation in acne, but the pathways involved are unclear. Here we reveal a mechanism that regulates inflammatory responses to P. acnes. We show that IL-1beta mRNA and the active processed form of IL-1beta are abundant in inflammatory acne lesions. Moreover, we identify P. acnes as a trigger of monocyte-macrophage NLRP3-inflammasome activation, IL-1beta processing and secretion that is dependent on phagocytosis, lysosomal destabilization, reactive oxygen species, and cellular K(+) efflux. In mice, inflammation induced by P. acnes is critically dependent on IL-1beta and the NLRP3 inflammasome of myeloid cells. These findings show that the commensal P. acnes-by activating the inflammasome-can trigger an innate immune response in the skin, thus establishing the NLRP3-inflammasome and IL-1beta as possible therapeutic targets in acne. |
