| First Author | Qi X | Year | 2017 |
| Journal | Mucosal Immunol | Volume | 10 |
| Issue | 1 | Pages | 128-138 |
| PubMed ID | 27007676 | Mgi Jnum | J:296053 |
| Mgi Id | MGI:6466760 | Doi | 10.1038/mi.2016.25 |
| Citation | Qi X, et al. (2017) Critical role of caspase-8-mediated IL-1 signaling in promoting Th2 responses during asthma pathogenesis. Mucosal Immunol 10(1):128-138 |
| abstractText | Allergic asthma is a chronic inflammatory disorder of the airways that affects >300 million people worldwide. The pro-inflammatory cytokines interleukin (IL)-1alpha and IL-1beta have essential roles in the pathogenesis of asthma. However, the mechanisms underlying the production of IL-1 cytokines in allergic asthma remain unclear. In this study, we used a mouse model of ovalbumin-induced asthma to identify a crucial role for caspase-8 in the development of allergic airway inflammation. We further demonstrated that hematopoietic cells have dominant roles in caspase-8-mediated allergic airway inflammation. Caspase-8 was required for the production of IL-1 cytokines to promote Th2 immune response, which promotes the development of pulmonary eosinophilia and inflammation. Thus, our study identifies caspase-8 as a master regulator of IL-1 cytokines that contribute to the pathogenesis of asthma and implicates caspase-8 inhibition as a potential therapeutic strategy for asthmatic patients. |
