| First Author | Peters J | Year | 1992 |
| Journal | Genet Res | Volume | 59 |
| Pages | 237-8 (Abstract) | Mgi Jnum | J:103253 |
| Mgi Id | MGI:3608954 | Doi | 10.1017/S0016672300030512 |
| Citation | Peters J, et al. (1992) Koala, Koa, is associated with an inversion on mouse Chromosome 15. Genet Res 59:237-8 (Abstract) |
| abstractText | Full text of Abstract: Abstracts of papers. Koala, Koa, is associated with an inversion on mouse chromosome 15. J. PETERS, C. TEASE AND S.T. BALL. MRC Radiology Unit, Chilton, Didcot, Oxon OX11 ORD Koala, Koa, was found among the progeny of a C3H/HeH male mouse treated with (3-0 + 3-0) Gy X-rays 24 h apart, such that the affected germ cell stage was spermatogonial stem cells. Koa/+ have a bushy muzzle and the pinna is densely covered with hair; in addition to these features Koa/Koa have open eyelids at birth and are smaller than their Koa/+ or +/+ litter mates. Genetic studies show that Koa is tightly linked to Ca, caracul, on chromosome 15 (0/400 recombinants) and suppresses recombination between Ca and bt, belted. Cytogenetic investigations have been carried out and suggest that a paracentric inversion has occurred in the distal half of chromosome 15. Meiotic analyses of synaptonemal complex preparations showed part paired inversion loops in 8% of cells and mitotic studies of G-banded chromosomes have revealed that Koa is associated with an inversion extending from 15D2 to 15F. Another mutation Eh, hairy ears, affecting the amount of hair on the pinna had been described earlier and had also been shown to be associated with a paracentric inversion extending from 15D2 to near the end of chromosome 15 [Davisson et al. (1990) Genet. Res. 56, 167-168]. No recombination has been found between Koa and Eh in 422 mice. Thus there are now two mutations, Koa and Eh which affect the amount of hair on the pinna and are associated with paracentric inversions with similar breakpoints on chromosome 15. |
