| First Author | Takeuchi O | Year | 2000 |
| Journal | Int Immunol | Volume | 12 |
| Issue | 1 | Pages | 113-7 |
| PubMed ID | 10607756 | Mgi Jnum | J:110454 |
| Mgi Id | MGI:3640248 | Doi | 10.1093/intimm/12.1.113 |
| Citation | Takeuchi O, et al. (2000) Cellular responses to bacterial cell wall components are mediated through MyD88-dependent signaling cascades. Int Immunol 12(1):113-7 |
| abstractText | MyD88 is an adaptor molecule essential for signaling via the Toll-like receptor (TLR)/IL-1 receptor family. TLR4 is a member of the TLR family and a point mutation in the Tlr4 gene causes hyporesponsiveness to lipopolysaccharide (LPS) in C3H/HeJ mice. We have previously shown that both TLR4- and MyD88-deficient mice are hyporesponsive to LPS. In this study we examined the responsiveness of these two knockout mice to various bacterial cell wall components. Cells from TLR4-deficient mice responded to several kinds of LPS, peptidoglycan and crude cell wall preparation from Gram-positive bacteria and mycobacterial lysates. In contrast, macrophages and splenocytes from MyD88-deficient mice did not respond to any of the bacterial components we tested. These results show that MyD88 is essential for the cellular response to bacterial cell wall components. |
