| First Author | Pichlmair A | Year | 2006 |
| Journal | Science | Volume | 314 |
| Issue | 5801 | Pages | 997-1001 |
| PubMed ID | 17038589 | Mgi Jnum | J:114834 |
| Mgi Id | MGI:3690241 | Doi | 10.1126/science.1132998 |
| Citation | Pichlmair A, et al. (2006) RIG-I-mediated antiviral responses to single-stranded RNA bearing 5'-phosphates. Science 314(5801):997-1001 |
| abstractText | Double-stranded RNA (dsRNA) produced during viral replication is believed to be the critical trigger for activation of antiviral immunity mediated by the RNA helicase enzymes retinoic acid-inducible gene I (RIG-I) and melanoma differentiation-associated gene 5 (MDA5). We showed that influenza A virus infection does not generate dsRNA and that RIG-I is activated by viral genomic single-stranded RNA (ssRNA) bearing 5'-phosphates. This is blocked by the influenza protein nonstructured protein 1 (NS1), which is found in a complex with RIG-I in infected cells. These results identify RIG-I as a ssRNA sensor and potential target of viral immune evasion and suggest that its ability to sense 5'-phosphorylated RNA evolved in the innate immune system as a means of discriminating between self and nonself. |
