| First Author | Wallace ME | Year | 1963 |
| Journal | Mouse News Lett | Volume | 28 |
| Pages | 22 | Mgi Jnum | J:33328 |
| Mgi Id | MGI:80808 | Citation | Wallace ME (1963) Milky (ml), a new mutant (now = Nil). Mouse News Lett 28:22 |
| abstractText | Full text of MNL contribution: "Milky", a new mutant. From a single female of Strain A(A/Cam), seen by Tatchell to be "milkyÓ at a few days old, a stock has been set up. "Milky" mice are classifiable at 0-5 days old by the presence of a white fluid in the small intestine, visible through the belly skin. Autopsy at 0-15 days usually discloses inflammation of the small intestine with numerous angiomatoses in the region enclosing the white fluid: the inflamed region extends in some older mice to the caecum and colon; less often there is a small amount of white fluid in the peritoneum. Expression is variable, as also is viability in the nest; breeding tests indicate a single dominant, heterozygotes having almost full penetrance, and homozygotes a greater expression and less viability than heterozygotes. The symbol Ml is proposed. (Note: now Nil). Allelism with the abdominal anomaly in our Ragged mice (MNL 21, p.25) is being tested, but differences between the two in expression and penetrance indicate a separate locus. In both heterozygotes, expression is manifest only after suckling has begun, so that the onset of feeding is clearly a phenocritical period. (Wallace, ME) |
