| First Author | Miyawaki S | Year | 1994 |
| Journal | Eur J Immunol | Volume | 24 |
| Issue | 2 | Pages | 429-34 |
| PubMed ID | 8299692 | Mgi Jnum | J:16865 |
| Mgi Id | MGI:64924 | Doi | 10.1002/eji.1830240224 |
| Citation | Miyawaki S, et al. (1994) A new mutation, aly, that induces a generalized lack of lymph nodes accompanied by immunodeficiency in mice. Eur J Immunol 24(2):429-34 |
| abstractText | We have found a new spontaneous autosomal recessive mutation in mice that causes a systemic absence of lymph nodes and Peyer's patches. The name alymphoplasia, with the gene symbol aly, is proposed for this mutant. The spleen of aly/aly mice is devoid of well-defined lymphoid follicles, and the thymus does not show a clear cortical-medullary distinction. The mutant homozygotes are deficient in both humoral and cell-mediated immune functions, and are highly susceptible to infections. They have a reduced level of IgM and severely depressed levels of IgG and IgA in their sera, and do not reject allogeneic skin grafts. However, they have mature T and B cells as determined from their cell surface antigens. The results of bone marrow transplantation experiments suggest a mesenchymal disorder as a possible cause of the lack of lymph nodes and of immunodeficiency in the aly mouse. The aly mutant mouse may be a useful animal model of primary immunodeficiency, as are the nu (nude) and scid (severe combined immunodeficiency) mice. |
