| First Author | Mair F | Year | 2015 |
| Journal | Elife | Volume | 4 |
| PubMed ID | 26637788 | Mgi Jnum | J:260103 |
| Mgi Id | MGI:6148444 | Doi | 10.7554/eLife.10087 |
| Citation | Mair F, et al. (2015) The NFkappaB-inducing kinase is essential for the developmental programming of skin-resident and IL-17-producing gammadelta T cells. Elife 4:e10087 |
| abstractText | gammadelta T cells contribute to first line immune defense, particularly through their ability for rapid production of proinflammatory cytokines. The cytokine profile of gammadelta T cells is hard-wired already during thymic development. Yet, the molecular pathways underlying this phenomenon are incompletely understood. Here we show that signaling via the NFkappaB-inducing kinase (NIK) is essential for the formation of a fully functional gammadelta T cell compartment. In the absence of NIK, development of Vgamma5(+) dendritic epidermal T cells (DETCs) was halted in the embryonic thymus, and impaired NIK function caused a selective loss of IL-17 expression by gammadelta T cells. Using a novel conditional mutant of NIK, we could show in vivo that NIK signaling in thymic epithelial cells is essential for the thymic hardwiring of gammadelta T cell cytokine production. |
