| First Author | Lalanne AI | Year | 2010 |
| Journal | J Immunol | Volume | 184 |
| Issue | 10 | Pages | 5678-85 |
| PubMed ID | 20400700 | Mgi Jnum | J:160995 |
| Mgi Id | MGI:4456918 | Doi | 10.4049/jimmunol.0903854 |
| Citation | Lalanne AI, et al. (2010) CpG inhibits pro-B cell expansion through a cathepsin B-dependent mechanism. J Immunol 184(10):5678-85 |
| abstractText | TLR9 is expressed in cells of the innate immune system, as well as in B lymphocytes and their progenitors. We investigated the effect of the TLR9 ligand CpG DNA on the proliferation of pro-B cells. CpG DNA inhibits the proliferation of pro-B, but not pre-B, cells by inducing caspase-independent cell death through a pathway that requires the expression of cathepsin B. This pathway is operative in Rag-deficient mice carrying an SP6 transgene, in which B lymphopoiesis is compromised, to reduce the size of the B lymphocyte precursor compartments in the bone marrow. Thus, TLR9 signals can regulate B lymphopoiesis in vivo. |
