| First Author | Sarween N | Year | 2004 |
| Journal | J Immunol | Volume | 173 |
| Issue | 5 | Pages | 2942-51 |
| PubMed ID | 15322152 | Mgi Jnum | J:277502 |
| Mgi Id | MGI:6295454 | Doi | 10.4049/jimmunol.173.5.2942 |
| Citation | Sarween N, et al. (2004) CD4+CD25+ cells controlling a pathogenic CD4 response inhibit cytokine differentiation, CXCR-3 expression, and tissue invasion. J Immunol 173(5):2942-51 |
| abstractText | It is well established that CD4(+)CD25(+) regulatory T cells (Tregs) inhibit autoimmune pathology. However, precisely how the behavior of disease-inducing T cells is altered by Tregs remains unclear. In this study we use a TCR transgenic model of diabetes to pinpoint how pathogenic CD4 T cells are modified by Tregs in vivo. We show that although Tregs only modestly inhibit CD4 cell expansion, they potently suppress tissue infiltration. This is associated with a failure of CD4 cells to differentiate into effector cells and to up-regulate the IFN-gamma-dependent chemokine receptor CXCR-3, which confers the ability to respond to pancreatic islet-derived CXCL10. Our data support a model in which Tregs permit T cell activation, yet prohibit T cell differentiation and migration into Ag-bearing tissues. |
