| First Author | Schroeder JH | Year | 2023 |
| Journal | Front Immunol | Volume | 14 |
| Pages | 1113735 | PubMed ID | 37114052 |
| Mgi Jnum | J:345812 | Mgi Id | MGI:7467682 |
| Doi | 10.3389/fimmu.2023.1113735 | Citation | Schroeder JH, et al. (2023) CD90 is not constitutively expressed in functional innate lymphoid cells. Front Immunol 14:1113735 |
| abstractText | Huge progress has been made in understanding the biology of innate lymphoid cells (ILC) by adopting several well-known concepts in T cell biology. As such, flow cytometry gating strategies and markers, such as CD90, have been applied to indentify ILC. Here, we report that most non-NK intestinal ILC have a high expression of CD90 as expected, but surprisingly a sub-population of cells exhibit low or even no expression of this marker. CD90-negative and CD90-low CD127(+) ILC were present amongst all ILC subsets in the gut. The frequency of CD90-negative and CD90-low CD127(+) ILC was dependent on stimulatory cues in vitro and enhanced by dysbiosis in vivo. CD90-negative and CD90-low CD127(+) ILC were a potential source of IL-13, IFNgamma and IL-17A at steady state and upon dysbiosis- and dextran sulphate sodium-elicited colitis. Hence, this study reveals that, contrary to expectations, CD90 is not constitutively expressed by functional ILC in the gut. |
