| First Author | Chen J | Year | 1994 |
| Journal | Int Immunol | Volume | 6 |
| Issue | 8 | Pages | 1265-8 |
| PubMed ID | 7981152 | Mgi Jnum | J:22572 |
| Mgi Id | MGI:70430 | Doi | 10.1093/intimm/6.8.1265 |
| Citation | Chen J, et al. (1994) IL-2 receptor alpha chain expression during early B lymphocyte differentiation. Int Immunol 6(8):1265-8 |
| abstractText | The IL-2/IL-2 receptor (IL-2R) has been studied intensively because of its potential function in the development and regulation of the immune system. The IL-2R alpha chain has been shown to be expressed on CD4-CD8- thymocytes and activated T and B cells. In this report, we show that IL-2R alpha is also expressed on precursor B cells in the bone marrow. Its expression is initiated by functional rearrangement and expression of Ig mu heavy chain gene and is down-regulated when immature B cells mature and express IgD. Its potential function in early B cell differentiation is discussed in comparison with its role in thymocyte differentiation. |
