| First Author | Mullin M | Year | 2007 |
| Journal | FEBS Lett | Volume | 581 |
| Issue | 22 | Pages | 4309-17 |
| PubMed ID | 17716670 | Mgi Jnum | J:125154 |
| Mgi Id | MGI:3757780 | Doi | 10.1016/j.febslet.2007.07.077 |
| Citation | Mullin M, et al. (2007) The RhoA transcriptional program in pre-T cells. FEBS Lett 581(22):4309-17 |
| abstractText | The GTPase RhoA is essential for the development of pre-T cells in the thymus. To investigate the mechanisms used by RhoA to control thymocyte development we have used Affymetrix gene profiling to identify RhoA regulated genes in T cell progenitors. The data show that RhoA plays a specific and essential role in pre-T cells because it is required for the expression of transcription factors of the Egr-1 and AP-1 families that have critical functions in thymocyte development. Loss of RhoA function in T cell progenitors causes a developmental block that pheno-copies the consequence of losing pre-TCR expression in Recombinase gene 2 (Rag2) null mice. Transcriptional profiling reveals both common and unique gene targets for RhoA and the pre-TCR indicating that RhoA participates in the pre-TCR induced transcriptional program but also mediates pre-TCR independent gene transcription. |
