| First Author | Shreedhar V | Year | 1999 |
| Journal | Immunity | Volume | 11 |
| Issue | 5 | Pages | 625-36 |
| PubMed ID | 10591187 | Mgi Jnum | J:58714 |
| Mgi Id | MGI:1349515 | Doi | 10.1016/s1074-7613(00)80137-5 |
| Citation | Shreedhar V, et al. (1999) Dendritic cells require T cells for functional maturation in vivo. Immunity 11(5):625-36 |
| abstractText | We examined dendritic cell (DC) status in SCID and RAG2 -/- mice to assess the influence of T cells on DC development and function in vivo. These mice have reduced numbers of DC in the epidermis and lymph nodes draining hapten-sensitized skin. Epidermal DC in these mice were defective in presenting antigen in vivo to adoptively transferred, hapten-sensitized T cells from normal mice. Likewise, draining lymph node DC were deficient in their capacity to stimulate naive T cells in vitro and in vivo. DC numbers as well as the impaired ability to present antigen in vivo, were corrected by reconstituting these animals with normal T lymphocytes, suggesting that T cells are crucial for normal DC maturation and function in vivo. |
