| First Author | Kirberg J | Year | 1994 |
| Journal | J Exp Med | Volume | 180 |
| Issue | 1 | Pages | 25-34 |
| PubMed ID | 8006585 | Mgi Jnum | J:86429 |
| Mgi Id | MGI:2679872 | Doi | 10.1084/jem.180.1.25 |
| Citation | Kirberg J, et al. (1994) Thymic selection of CD8+ single positive cells with a class II major histocompatibility complex-restricted receptor. J Exp Med 180(1):25-34 |
| abstractText | We describe mice that express a transgenic T cell receptor alpha/beta (TCR-alpha/beta) specific for peptide 111-119 from influenza hemagglutinin presented by I-Ed class II major histocompatibility complex (MHC) molecules. The transgenic TCR is expressed on CD4+8- as well as CD4-8+ mature T cells even in mice that are deficient in rearrangement or do not express endogenous TCR-alpha genes. The CD4-8+ T cells require I-Ed class II MHC molecules for positive selection and can be activated to proliferate and to kill by I-Ed molecules presenting the relevant peptide. Full maturation of these cells, however, also requires the presence of class I MHC molecules. The results are compatible with the notion that T cell maturation requires multiple receptor-ligand interactions and establish an exception to the rule that class II-restricted TCRs are exclusively expressed by mature CD4+8- cells. |
