| First Author | Monzón-Casanova E | Year | 2018 |
| Journal | Nat Immunol | Volume | 19 |
| Issue | 3 | Pages | 267-278 |
| PubMed ID | 29358707 | Mgi Jnum | J:282394 |
| Mgi Id | MGI:6380796 | Doi | 10.1038/s41590-017-0035-5 |
| Citation | Monzon-Casanova E, et al. (2018) The RNA-binding protein PTBP1 is necessary for B cell selection in germinal centers. Nat Immunol 19(3):267-278 |
| abstractText | Antibody affinity maturation occurs in germinal centers (GCs), where B cells cycle between the light zone (LZ) and the dark zone. In the LZ, GC B cells bearing immunoglobulins with the highest affinity for antigen receive positive selection signals from helper T cells, which promotes their rapid proliferation. Here we found that the RNA-binding protein PTBP1 was needed for the progression of GC B cells through late S phase of the cell cycle and for affinity maturation. PTBP1 was required for proper expression of the c-MYC-dependent gene program induced in GC B cells receiving T cell help and directly regulated the alternative splicing and abundance of transcripts that are increased during positive selection to promote proliferation. |
