| First Author | Lazarevic V | Year | 2009 |
| Journal | Nat Immunol | Volume | 10 |
| Issue | 3 | Pages | 306-13 |
| PubMed ID | 19169262 | Mgi Jnum | J:146134 |
| Mgi Id | MGI:3836819 | Doi | 10.1038/ni.1696 |
| Citation | Lazarevic V, et al. (2009) The gene encoding early growth response 2, a target of the transcription factor NFAT, is required for the development and maturation of natural killer T cells. Nat Immunol 10(3):306-13 |
| abstractText | The influence of signals transmitted by the phosphatase calcineurin and the transcription factor NFAT on the development and function of natural killer T (NKT) cells is unclear. In this report, we demonstrate that the transcription factor early growth response 2 (Egr2), a target gene of NFAT, was specifically required for the ontogeny of NKT cells but not that of conventional CD4(+) or CD8(+) T cells. NKT cells developed normally in the absence of Egr1 or Egr3, which suggests that Egr2 is a specific regulator of NKT cell differentiation. We found that Egr2 was important in the selection, survival and maturation of NKT cells. Our findings emphasize the importance of the calcineurin-NFAT-Egr2 pathway in the development of the NKT lymphocyte lineage. |
