| First Author | Tanaka H | Year | 2004 |
| Journal | J Steroid Biochem Mol Biol | Volume | 89-90 |
| Issue | 1-5 | Pages | 343-5 |
| PubMed ID | 15225798 | Mgi Jnum | J:91345 |
| Mgi Id | MGI:3046589 | Doi | 10.1016/j.jsbmb.2004.03.021 |
| Citation | Tanaka H, et al. (2004) Direct action of 1,25-dihydroxyvitamin D on bone: VDRKO bone shows excessive bone formation in normal mineral condition. J Steroid Biochem Mol Biol 89-90:343-5 |
| abstractText | In the present study, the direct role of Vitamin D in bone metabolism was investigated. Vitamin D has been suggested to be an important hormone for bone metabolism, but there has been little evidence that Vitamin D actively participates in this process. Here, we show the direct action of Vitamin D by transplanting the bone of the Vitamin D receptor null mutant mice (VDR-/-) to the wild-type mouse. This procedure allowed us to investigate the changes in the bone without VDR in the normal humoral environment. Unexpectedly, the volume and the density of the VDR-/- bone transplanted to the wild-type mouse were significantly increased compared with the control (wild-type bone transplanted to the wild-type mouse). We show that Vitamin D has key roles in bone metabolism negatively. |
