| First Author | D'Avila H | Year | 2007 |
| Journal | Infect Immun | Volume | 75 |
| Issue | 3 | Pages | 1507-11 |
| PubMed ID | 17158890 | Mgi Jnum | J:118500 |
| Mgi Id | MGI:3699683 | Doi | 10.1128/IAI.01326-06 |
| Citation | D'Avila H, et al. (2007) Toll-Like Receptor-2-Mediated C-C Chemokine Receptor 3 and Eotaxin-Driven Eosinophil Influx Induced by Mycobacterium bovis BCG Pleurisy. Infect Immun 75(3):1507-11 |
| abstractText | An acute and persistent eosinophil infiltration is observed during Mycobacterium bovis BCG pleural infection in mice. Eosinophil accumulation, lipid body formation, and eotaxin production were significantly reduced in BCG-infected Toll-like receptor-2 (TLR2)-deficient mice compared to wild-type mice. Neutralization of eotaxin or CCR3 drastically inhibited BCG-induced eosinophil accumulation and lipid body formation, indicating that BCG-induced eosinophil recruitment and activation is largely dependent of TLR2-mediated eotaxin generation. |
