| First Author | Vogel SN | Year | 1979 |
| Journal | J Immunol | Volume | 122 |
| Issue | 2 | Pages | 619-22 |
| PubMed ID | 368244 | Mgi Jnum | J:6086 |
| Mgi Id | MGI:54563 | Doi | 10.4049/jimmunol.122.2.619 |
| Citation | Vogel SN, et al. (1979) Characterization of a congenitally LPS-resistant, athymic mouse strain. J Immunol 122(2):619-22 |
| abstractText | C57BL/10ScN (nu/nu) mice have B cells and macrophages unresponsive to a phenol-water extracted preparation of Escherichia coli K 235 LPS. This unresponsiveness was demonstrated in vitro by the inability of spleen cells to incorporate 3H-thymidine after a 48 hr incubation with LPS (Ph) and by the inability of LPS (Ph) to inhibit macrophage phagocytosis of 51 Cr-labeled, opsonized sheep erythrocytes. Furthermore, macrophage cultures stimulated with LPS (Ph) produced low levels of LAF and PGE2 when compared with macrophages from the LPS-sensitive C3H/HeN and C3H/HeN (nu/nu) strains. Therefore, the C57BL/10ScN (nu/nu) strain is similar in its LPS unresponsiveness to the well-characterized C3H/HeJ and C57BL/10ScCR strains. The combination of endotoxin unresponsiveness and the athymic nature of this mouse strain may provide a powerful new tool for studying the cellular events mediating endotoxicity. |
